Be Nice To Yourself and Don’t Buy Supplements Online

Buying supplements online seems like a good idea, a cheap way to get supplements we want or can’t get in our country. I’m Canadian and some stuff just isn’t available here. I admit, I used to be a bit of a diet pill junky, or collector. I’d buy the stupid things and take a couple, get sick, and throw them all out when I got busted by my mom. I did that for 8 years. I wasted a lot of money. I admit, I still scour the Internet for diet pills. Bad habit. I don’t use them anymore, but I find them interesting.

simpsons

I am a very pro-treatment and pro-medication kind of gal. I’ve never found that naturopaths or homeopaths have worked for me, but I know those they’ve worked very well for. I’ve tried over the counter stuff for my bipolar disorder and it hasn’t worked. If it’s worked for you, great. Feel free to share experiences. I won’t deny that over the counter stuff works, it has helped me with other problems (pain, PMS, cramps. I hate painkillers, for example). I also won’t deny that it isn’t as tightly regulated as it should be, and that it can be dangerous. People need to see their doctors before taking it and follow precautions, especially if they mix it with meds. These are medications, too, just not as tightly regulated.

People are wary of prescription drugs. In the US, in one year, they spent $26.7 billion(1) on non-prescription supplements. I’m making a guess at this, but there is less guilt in taking something over the counter, less embarrassment than asking your doctor? It seems the world is split, some avoid prescription meds, and some overuse them. The happy medium isn’t big enough!

The FDA and a subsection (Dietary Supplement Health and Education Act DSHEA) have found:
– Some supplements found in stores and online can cause heart, kidney and liver problems with no warnings.
– There is little to no quality control and toxic substances such as pesticides, heavy metals or (for some strange reason) even prescription drugs are being sold with no knowledge to the customer.
– China is a major supplier of raw ingredients, which are often contaminated, have never had their factories inspected by the FDA.
Many products also exaggerate their claims, meaning, they say the supplement can prevent, treat or cure a disease. This is harmful advice, and this is illegal.
Consumers of the products often have no idea
A lot of the users of the supplements don’t know what they’re getting. It’s like a surprise, but it can hurt or kill you! A lot of vitamins and supplements purchased online contain very little nutritional value and can kill you, your kids or your pet. Seriously, if they get into them. There are a few reasons why buying online is a bad idea(2).

counterfeit

1. A medication can be “counterfeit” and dangerous. (I’m picturing a pill in fake Adidas with an Ak-47)
2. The product has probably expired, if it is real, and the seller has repackaged it for resale.
And for the best one 3. It’s stolen. No quality control.

If you can’t get it at home, don’t order it online. This includes even Amazon.

Counterfeit?
Counterfeit basically means “fake”, or “ripped off”. This is different from medications where there is a brand name and a generic, because the generic actually has real ingredients in it. A counterfeit mediction just looks real. It doesn’t act real. It’s never going to have as much active ingredient as it claims, and if you check out the link to where I’m getting this info, you’re literally paying a lot for a little bit of sawdust, according to the FDA.

roundup

Note: The criminals rarely get charged because it’s too hard to figure out who to charge, where it began and so on. Sad. This is costing a lot of money, $600 billion, to be, well, estimated, which is almost as much as terrorism costs. Cheap is so tempting, but it’s not legit.

Expired
All medications expire and can do weird things after they do. They can become more potent, less potent, or make you change colours and see things (or make you see yourself change colour?) It’s a bad idea to take that expired cough syrup. You’ll probably cough it back up into the toilet, for example, if you’re lucky. Generally a medication or supplement is good for 6-12 months after being filled at the pharmacy. Sometimes longer. Selling an expired product is illegal, its dangerous, because the product may or may not work, it could make you sick, and all the criminal has to do is slap a new date on the package.

expired

They can get any amount of $ they want. The pills aren’t counterfeit. If someone complains it doesn’t work, the “seller” and throw them a few good pills, or ignore it. Nobody knows exactly how effective this stuff is anyways. It’s a dangerous game when you buy online. Here’s a link on expired medications: http://www.rxlist.com/script/main/art.asp?articlekey=87599

As for stolen, well, that’s self explanatory. You could get a good product once, a bad product another time. Hit or miss.

When In Doubt
If you’re going to use supplements:
1. Don’t buy them online. Go to a local health food store.
2. See your doctor and pharmacist. Check for interactions. Get that physical every year, or every other year. Some doctors are very open to supplements. I know many that have a few concoctions for PMS and cramps!
3. Don’t take anything for weight loss, sexual ehancement or building muscle.
4. If it’s from the US, or you’re living in the US, it has a “USP Verified”(3) mark on the bottle. Their website is linked below with everything they verify.
5. You CAN overdose. More is not better.
6. If something feels wrong, tell your doctor. If it’s really wrong, go to an emergency clinic, or the ER.

Safely Buying Supplements
1. Buy from the manufacturer or a reputable operation in your own country. Try not to cross borders. Do not import things illegal in your country. (For example, ephedra, easy to get OTC in Canada, is illegal in most USA States)
2. Reputable companies supply a lot more information, ingredients, quality control info, and websites with more info, and even have phone numbers.
3. Avoid really cheap stuff.
4. Avoid sites like ebay and amazon, this is your health!

1. http://www.consumerreports.org/cro/2012/05/dangerous-supplements/index.htm
2.http://www.garyshealthtips.com/why-you-should-never-buy-supplements-on-amazon-or-ebay-a-must-read-by-former-fda-special-agent-gary-collins/wn

3. http://www.usp.org/usp-verification-services/usp-verified-dietary-supplements

Advertisements

I suck. And I’ll start updating more, too.

August 1 2008 I had been discharged from my longest hospitalization.

form1

October 7th, 2013 I was hospitalized until October 24th because the stress of life, the universe and everything kicked in and I broke down. Of course, no beds on my Dr’s unit, so he loopholed me through PERT – Psychiatric Emergency Resource Team. They had an emergency room physician come in and put me on a Form 1. 72 hour involuntary hold. Dr N, my pdoc, was not impressed. He took me off it when I was transferred to Unit B, the ward he works on. I was a danger to myself. What crap.

I had a panic attack when they handed me the Form 42 (copy of the Form 1). PERT is just seclusion rooms. Luckily, I wasn’t locked in. They nurse gave me some Ativan and a heated blanket. I slept. BF showed up. He brought McDonalds. My friends took my car back to the apartment. The next day I was transferred to Unit B, where my pdoc works. I had a private room. It was BF’s birthday. He saw me anyways. I owed him big for that!  They tried to give me Ritalin at 10pm, night meds. I refused it. They charted I was “refusing meds”.  My pdoc laughed the next day, thankfully, saying it was good I knew to refuse Ritalin at 10pm! He then told them to NEVER give it to me after 4pm.

Pdoc was good to me. Saw me daily. I had a pass for Canadian Thanksgiving. It sucked, my dad was drunk and being an ass. It was a short pass, thankfully, I had BF with me. “Oh, back so soon.” Oh, yes. BF went for his MRI results: No change in the tumor since his diagnosis a year ago!! MRI’s are yearly, now. At the best cancer centre in Canada, only 45 min away from us. He had a seizure last night. His neurologist is still working on the meds. Less bad, shorter seizures, but still minor seizures. No unconsciousness, no disorientation, but still.

So, we had a lot of groups. I met a couple cool people. I had a day pass, I went to the barn, went riding.

sparkle

That’s me on Sparkle. She’s a five year old, gigantic Thoroughbred filly. Her registered name is “Sparkle Tangerine”. I did some walk, trot, canter and a small jump. She was very good. Look how tiny I am on her!  I was exhausted when I got back.

I did all the groups. I got so sick of the religious crap from a lot of patients. There wasn’t a lot of super craziness like I’ve seen. No restraints used, no chemical restraints used. A few “code whites” (unmanageable or violent patient) called. I was going to go long term, but the beds weren’t available. Dr N saw staying on the ward was getting hard on me, and we agreed on discharge for the 24th. I start outpatient therapy next Tuesday for anxiety, stress. CBT, that sort of thing. One on one. The only cost is parking.

I now take Geodon (aka Zedox), Lexapro (Cipralex), Ritalin, Topamax, Clonazepam, mostly at lower doses, managing. and my normal meds for my health. I was diagnosed with endometriosis yesterday. BLAH. I start birth control (I’ve had a tubal ligation!!) after my period to try to ease the pain. If not, we do more drastic things. It’s not the worst thing in the world. The ultrasound could have shown a million WORSE things. (Endo is not detected on most ultrasounds) I’ve decided on rotator cuff surgery. Dr N was great to me in the hospital. I thanked him before I left, for his patients. The rec therapists were great. One I’ve known since 2002. We even had a ball pit!

That’s my life for now.

Lithium Orotate – Consult a Doctor First

Consult a doctor

Consult a doctor

Just a quick response to my lithium orotate article.
Lithium orotate is lithium. Simple as that, it is just a different chemical formation. I have been called all sorts of names, a liar, an advocate for “Big Pharma” and so on. Lithium carbonate is probably the same price – it’s an inexpensive drug and it’s monitored by pharmacies, labs and you can’t buy it easily online and you know what you’re getting (in an ideal world, at least, you should know). Levels should be checked.

Lithium is dangerous to the kidneys in any formula, yes. However, lithium orotate is more dangerous. It is an over the counter supplement. This does not mean “safe”. Tylenol is deadly to the liver, for example, and is sold anywhere. Take enough, and you’ll need a new liver. What a crap example, I know.

Lithium has to be at a certain level in the blood to be therapeutic for the patient. I’m in a country (Canada) with socialized healthcare. I get blood tests for free, I get my meds cheap, yes, I have that advantage. (I can’t take lithium, but it did help for many years, I did end up with mild kidney disease called “diabetes insipidous”) It’s not the safest drug, I know that from experience. It has shitty side effects. It hasn’t changed much over the years. But it works.

Lithium orotate is dangerous simply because anyone can get it. Online supplements are more dangerous because you don’t know what you’re getting. People tend to abuse something advertised as “natural”, because “natural” sounds safe. Look at things like diet pills from GNC, a year later, they get banned because people end up with heart problems. The “healthy living store”.

I’m not saying all natural supplements are bad. But they all say to take with the advice of a doctor. Self prescribing anything is a bad idea. Especially for a psychiatric illness as serious as bipolar disorder. Especially with something like lithium. Blood levels are generally reduced to every 6 months, sometimes less once a dose is established.

A few things to remember.
Natural is NOT always safe.
Always consult a doctor, whether it be a GP or psychiatrist, before taking any over the counter medication or supplement. It could interact with something you already take, or even eat.

Be cautious if you order something online. The dose might not be accurate. It could contain something you don’t know of. It could contain something you’re allergic to. It could contain something that could come up on a physical or blood test as a false negative or positive.

A health food store doesn’t exactly have the most qualified people to give medical advice. This is medicine we’re talking about. Your mind and body. Again, see a doctor.

If you experience any weird side effects STOP.

Be cautious. Nothing works the same way for two people.

This is all my opinion. I do not have any links for you.

Medications Part 4 – Atypical Antipsychotics Aren’t Just for Schizophrenia

A lot of people hear the word “antipsychotic” and shy away from the medication, or think they’re doomed. But in fact, atypical antipsychotics are quite useful in the treatment of bipolar disorder and depression.

 A few are even FDA approved for the use of either augmenting an antidepressant for someone with clinical or major depressive disorder, or as a mood stabilizer for bipolar disorder. I’ve been on atypical antipsychotics since I was 18, and must say, they have less side effects than the first generation ones, and they’re much more helpful. One, called Symbyax, is a pill of Zyprexa and Prozac paired for use in major depression and approved for bipolar depression as well.

 The main atypical antipsychotics are Abilify, Saphris, Fanapt, Latuda, Zyprexa, Symbyax, Invega, Seroquel, Risperdal, Geodon/Zeldox and Clozapine*.

 Antipsychotics, unfortunately, have the risk of major weight gain. I gained 40 pounds while on Zyprexa, it seemed to even out when I switched to Abilify. This can be off-putting for many of those prescribed these medications. Geodon, Clozapine and Abilify are considered “weight-neutral”, meaning they do not cause weight gain or loss(1) but your mileage may vary. I lose weight on Geodon.

 I found Risperdal to be a little sedating for a bit. But the big problem with many atypical antipsychotics (or AAP’s, for short) can cause your prolactin (a hormone) to go up. This, in females, can stop your period and cause “leaky breasts”. It’s not as much fun as it sounds, it’s downright gross and embarrassing to try to explain to your 70 year old shrink that your tits are leaking! Before I took Risperdal, I actually had to take medications to increase my prolactin levels, and I was taken off them before starting Risperdal.

 I find Risperdal to be a good “once in a while” medication. It doesn’t have the mood stabilizing effects that a lot of the others do. It helped with my irritability, but I’ve never been on it long enough to see it’s full effects. But my boobs went from a C to a DD. It is also available in a long acting injection. I don’t like long acting injections because once its in your system, it stays there, and until its completely out, you get the side effects.

 Saphris is a newer AAP and is not available in Canada, to my knowledge, and when swallowed, is only 10% effective, so, like Zyprexa Zydis, it has to be dissolved under the tongue. Reports say that it’s horribly disgusting tasting but it works. You also get a numb mouth for a little bit, which is always heaps of fun. Zyprexa Zydis doesn’t cause as much weight gain as Zyprexa itself, for some reason, and is good at knocking you right out, but there’s always that chalky feeling in your mouth the next day. Ick.

 Seroquel is one of the most well known AAP’s out there and is also known for causing a lot of weight gain. I never really gained on Seroquel, to be honest, and it made me stop smoking so much for some strange reason. Unfortunately I had weird side effects from it (heart arrythmia’s and trouble swallowing) so I had to stop taking it. At one point I was taking 900mg a day, enough to sedate a horse. No wonder I kept falling asleep in class! The dose I’ve noticed most people take is 300-600mg a day, usually at bedtime. It’s good in tiny doses (12.5mg, 25mg) for anxiety or a PRN (as needed) medication. It is also approved to be used with an antidepressant in bipolar and unipolar depression. Some people call it Slurrrroquel because of its sedating effects. It can be used as a mood stabilizer without a combination of an anti-convulsant.

 Geodon is one of my favourites, I honestly shouldn’t have switched to Abilify. Some people find Geodon (called Zeldox in most of the world, I’m using the USA name) very sedating, but I found it not-so-much. I often have trouble sleeping or staying asleep on it. It works as a mood stabilizer as well. It’s weight neutral but can cause akithasia, inner restlessness, something I’m feeling now due to Abilify. Abilify is considered a third generation antipsychotic, while the rest are second generations.

 Okay, this isn’t a review on AAP’s, so I’ll continue on with how they work, how they differ from “typical” antipsychotics and side effects.

 How do they work?

Like most psychiatric medication, they don’t really know how or why they work.(2) The theory is that they act on dopamine (a neurotransmitter) and block other neuroreceptors. Rispderal is said to block the creation of serotonin and dopamine, so the symptoms don’t show up, and Invega works the same way. Zyprexa, Seroquel and Clozapine block several receptors and try to fix the chemical imbalance in the brain, but unfortunately, do to this specific mechanism, type 2 diabetes is a possible side effect, as is weight gain. Abilify is unknown and Geodon is completely different, helping with positive and negative symptoms of schizophrenia, making it a good mood stabilizer.

 Side Effects

They say side effects only occur in 10% of those taking these meds(3) but honestly, I think its much more than that. Common side effects are: weight gain, tachycardia, insomnia, akathisia, agitation, anxiety, headache. It’s kind of funny because some of those side effects are what those medications treat.

 Rare side effects include: Dystonia(4), Parkinsonism(5), tardive dyskenesia and neuroleptic malignant syndrome, and sometimes type 2 diabetes.

 Atypical vs. Typical

Typical antipsychotics are sometimes called neurloeptics because it means “seize the neuron”(6) They tend to control symptoms such as mania, delusions and hallucinations, also called “positive symptoms”. (Do remember, that schizophrenia and bipolar work similarly in the brain) Side effects are similar, but worse, and can cause tardive dyskenesia (7), sometimes they are paired with medications like Cogentin to stop this.

 Though typical’s can treat positive symptoms, the negative symptoms are still there. In the 1980’s, researchers found a way to treat both sides of the spectrum, called atypical antipsychotics, that work on more receptors and have less severe side effects.

 “Researchers speculate that traditional antipsychotic medications completely block one kind of dopamine receptor, leaving other types of dopamine receptors unaffected. Atypical antipsychotics appear to block many kinds of dopamine receptors less completely.”

 

Danger! Lithium Orotate

If you do a basic Google search for this supplement, it will bring up things like:

  • Lithium orotate works!
  • Lithium orotate is NOT a prescription drug!
  • It is NOT toxic like lithium carbonate! (1)

Image

Well, what do you think when something sounds too good to be true?
It probably is.

Over the counter supplements can be extremely dangerous when put in the wrong hands. Diet pills are a good example. So many diet pills are put up and pulled down from the market in any given month, and serious side effects are later reported: heart failure, anxiety, liver or kidney problems. Sure, people abuse over the counter supplements because they think they are safe, but some over the counter supplements can do far worse than a prescription medication.

This article is probably going to piss some people off because I’m fairly anti-over-the-counter-supplement, unless I need something for my cough or flu. Vitamins are always a good idea, but you should still make sure you need them. Sometimes more is too much. This is my side, and many medical professionals, sides of lithium orotate. I’m not saying it’s going to immediately kill you, it may work, but tell your doctor, as with any supplement you may be taking because they can interact with other medications and dietary supplements too. I can’t stress that enough. Also, it isn’t allowed in Canada.

Let’s get started.

What is lithium orotate?
Another way of delivering lithium. Lithium carbonate is generally used in bipolar disorder in doses of 300mg and up. They claim that lithium orotate goes “straight to the brain”(2) but this is untrue because medications have to be processed by the body, mainly liver and kidneys, and the blood-brain barrier has it’s own defence system, which basically means, drugs don’t go directly to the brain. The barrier is needed to keep the brain and central nervous system healthy. It treats medications as an enemy, not allowing them through. (3)

Okay, so lithium orotate is just another method of delivering lithium to the body in hopes of it helping bipolar disorder, depression, anxiety, and whatever else.

Lithium orotate is a salt of lithium and orotic acid. There are no systematic reviews of the efficiency of lithium orotate for any condition. In 1979, it was found that lithium orotate was more dangerous to the kidneys than lithium carbonate.(4) Don’t forget about the thyroid! Lithium effects that, too.

Lithium attacks the kidneys. I know this because I have diabetes insipidus. People complain of symptoms such as urinating too much and being constantly thirsty on lithium orotate. I am not saying its causing diabetes insipidus in all the users, but that’s not necessarily good for you. Ok, I’ll stop giving you my opinion and give you some facts.

Lithium Toxicity from Internet Dietary Supplement (5)
The internet has made it easier to get supplements, and easier to overdose on them. An 18 year old woman presented in the emergency room after taking 18 tablets of a lithium orotate based product, each containing 120mg of lithium. She had a low lithium level, was vomitting, and given IV fluids. 90 minutes later, her lithium level was higher, and she was transferred to a psychiatric ward with stable vital signs, but also lithium toxicity.

Lithium orotate is not FDA approved. (6)
There is no research of it being used on humans, but it is available online to anybody.

Lithium orotate releases more lithium into the body than lithium carbonate, bringing us back to kidney issues. Kidney disease, kidney failure, and death. Talk to your doctor. Don’t believe everything you read, take caution, and read the bottle. Unlike a prescription bottle, whose to say if the information is accurate?

“Controversial claims regarding the actual benefits and side effects of lithium orotate are widespread. Much of the debate centers around the last recorded study done on rats in 1979 by Smith and Schou. In the study, equal amounts of all three lithium derivatives were given to the rats. The results indicated that lithium orotate was not eliminated by the rats’ kidneys, unlike the other two brands.” (7)

So what am I trying to say?
Lithium orotate could help you. Or it could not. It could damage your kidneys or kill you. If you need to be on lithium, get it through your doctor or psychiatrist, not off the internet. It’s been used since the 1970’s. You need kidneys and the risk of damage is lowered when a physician is having regular levels drawn and monitoring your treatment.

(1) http://mysite.verizon.net/res003jh/lithium-orotate/
(2) http://www.marsvenus.com/p/lithium-orotate
(3) http://www.health.umn.edu/research/corridors/brain/blood-brain-barrier/index.htm
(4) http://www.ncbi.nlm.nih.gov/pubmed/34690
(5) http://www.ncbi.nlm.nih.gov/pubmed/18072162
(6) http://www.ehow.com/about_5531532_lithium-orotate-information.html
(7) http://www.ehow.com/about_4614151_side-effects-lithium-orotate.html

The Devil and God are raging inside of me

Hell on Earth: Bipolar “Mixed States”

Image

Bipolar I, and Bipolar II (was just updated in the DSM5), all tend to come with a symptom that isn’t quite mania nor depression. It can also be called dysphoric mania. It’s like taking the two, throwing them in the blender and see what you get. You can be depressed with a lot of energy (example: racing mind, many suicides are attempted in mixed states) or manic with depressed thoughts.(1) I find myself incredibly irritable and angry during a mixed state.

 

Sounds fun, eh?

It’s not, at all, even closely remotely to being fun.

 

The DSM-IV defines a mixed episode as a period of at least 1 week in which the criteria for both a major depressive episode (MDE) and a manic episode are met nearly every day. During a mixed episode, an individual experiences rapidly alternating periods of sadness and irritability and of euphoria accompanied by symptoms of a manic episode”(2)

 

Some symptoms include: agitation, insomnia, appetite dysregulation, psychotic features and suicidal thinking. At least 40% of those with bipolar disorder have at least one mixed state in their life. There is a greater rate of suicide, substance abuse (which definitely won’t help it!) It is literally mania littered with depression.

 

Those with mixed symptoms are generally diagnosed at an earlier age with rapid cycling, suicide attempts, more irritability and Bipolar 1. It affects more women than men.

 

Mixed episodes are difficult to treat, both states have to be identified, and works best if caught early (and can prevent future mixed episodes from occuring.) The treatment, for the most part, is medication, like Lithium or Depakote. Antidepressants can make the mixed state worse, or blow up into full mania. Mixed states have also been mistaken for ultradian cycling bipolar disorder. Mood stabilizers, antipsychotics (preferably atypicals) help with mixed episodes, and ECT(3) can also be used to zap you out of it. An antidepressant might be temporarily used, but as I said, it can do more bad than good.

 

Over the years, I’ve had a few mixed episodes. I have bipolar type 1 with rapid cycling. After ECT, my highs and lows weren’t as drastic, but I still get mixed states.

 

If you’re in a mixed state, or someone close to you thinks you are, please, go to a hospital before it gets worse.

 

 

  1. http://www.nimh.nih.gov/health/publications/bipolar-disorder/complete-index.shtml

  2. http://newsletter.qhc.com/CP/CP_BMS2.html

  3. http://www.webmd.com/bipolar-disorder/guide/mixed-bipolar-disorder

Mania slowly eats your brain (seriously)

Mania, the horrible mistress of bipolar disorder. We sometimes take it for granted in it’s early stages, hypomania, but in a full blown out manic episode, everything can go to hell. Many people accidentally kill themselves in manic episodes. But did you know, that during an episode, you’re killing your brain?

“Episodes of mania and depression may cause damage to learning and memory systems”(1)

Long term patients showed more cognitive impairment than those younger, or newly diagnosed. Bipolar disorder and time are not your friends. After 5-7 years, the newly diagnosed showed some cognitive impairment.

It can be blamed on medications, but that’s untrue. They can cause cognitive slowing but they aren’t a culprit. Some medications even repair parts of the brain, and are considered to have neuroprotective properties.

The brain breaks down as the disease goes on, and it isn’t able to process information the way it used to. (Remember, bipolar is a kindling disease, if left untreated, it just gets worse and worse, and the damage increases per episode)

“People with bipolar disorder suffer from an accelerated shrinking of the brain”(2)

Gray matter in the brain is lost during an episode, in the areas of the brain that control memory, face recognition and co-ordination.

“Evidence has been overwhelming that bipolar disorder is a disease of the brain, like Parkinson’s or MS”(3)

Those with bipolar disorder have enlarged ventricles in the brain and extra white matter, for example. Impaired awareness (50% of those with bipolar disorder are aware of their disease, diagnosed or not) is because of decreased activity in the pre-frontal area. This is similar to a stroke victim.

Results of MRI’s from the mentally interesting and people without mental illness show that those without mental illness had more gray matter in their brains.(4) Gray matter is consisted of nerve cells. An essential amino acid, called NAA, was monitored in bipolar patients and the amount decreased as the illness progressed, which indicates damage to neurons. These findings are comparable in Alzheimer’s.

In conclusion, if you’ve been diagnosed with bipolar disorder and want to make the best of your life, take your medications, live a healthy lifestyle, don’t drink or do drugs and learn some insight to get proper treatment before an episode happens.

And just remember this: What goes up, must come down.

  1. http://www.healthyplace.com/bipolar-disorder/articles/brain-damage-from-bipolar-disorder/

  2. http://www.sciencedaily.com/releases/2007/07/070720103036.htm

  3. http://www.pendulum.org/disease.htm

  4. http://www.ehow.com/about_5245785_effects-bipolar-disorder-brain.html